Search results for " Serotonergic Neurons"

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The existence of FGFR1-5-HT1A receptor heterocomplexes in midbrain 5-HT neurons of the rat: relevance for neuroplasticity.

2012

The ascending midbrain 5-HT neurons to the forebrain may be dysregulated in depression and have a reduced trophic support. Within situproximity ligation assay (PLA) and supported by coimmunoprecipitation and colocation of the FGFR1 and 5-HT1A immunoreactivities in the midbrain raphe cells, evidence for the existence of FGFR1–5-HT1A receptor heterocomplexes in the dorsal and median raphe nuclei of the Sprague Dawley rat as well as in the rat medullary raphe RN33B cells has been obtained. Especially after combined FGF-2 and 8-OH-DPAT treatment, a marked and significant increase in PLA clusters was found in the RN33B cells. Similar results were reached with the FRET technique in HEK293T cells,…

Retractedmedicine.medical_specialtySerotonin receptorsEncèfalSettore BIO/11 - Biologia MolecolareBiologySettore BIO/09 - FisiologiaReceptors de serotoninaMidbrainInternal medicineRatesmedicineReceptor5-HT receptorNeuronal Plasticity Receptor Fibroblast Growth Factor Receptor Serotonin 5-HT1A Serotonergic Neurons SerotoninRapheGeneral NeuroscienceEncephalonFibroblastsRatsEndocrinologymedicine.anatomical_structurenervous systemForebrainAutoreceptor5-HT1A receptorNeuron

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